Why Viagra/Sildenafil Does Not Work For Some

questionViagra works by inhibiting the PDE enzymes that lead to degradation of cyclic guanosine monophosphate, which relax the vascular muscles leading to an increased blood flow to the penis causing good strong erections in men and for these activating purposes, it is very commonly known as the “miracle pill”. There are however certain cases of  Erectile Dysfunctions where in Viagra fails to work. We will in this article try to identify the reasons for such failure.

  • The first reason for inaction of Viagra on sexual function could be the immunisation of the body towards PDE inhibitors like Viagra and Cialis. This means, the PDE enzymes get used to a certain dosage of the drug and device a mechanism to overrule it. It does not happen to everyone but has been noticed in some and in such cases the dosage of the drug may be increased in consultation with the doctors.
  • Another reason for failure, although rare, is the incapability of blood retention into the spongy tissues of the penis which is responsible for creating pressure that increases the penile size. When the blood escapes the region and cannot create the pressure for the penile size to increase.
  • Low levels of testosterone hormone also lead to lack of proper erections, even in the case of Viagra dosages. As described earlier, Testosterone plays a major role in development of sexual parts and is also responsible for good libido. Extremely low levels of testosterone can lead to improper development in size, referred to as atrophy, of several sex tissues leading to disfigured or underdeveloped sexual parts and any external influences like PDE inhibitors fail to rework this.
  • Nitric Acid works on the small blood vessels like those in the penis and allow blood flow to increase thereby causing an erection. In several cases, especially after of the age of forty, the production of Nitric Acid depletes. Nitric Oxide deficiency can occur due to nerve damage  more common in chain smokers or occurs with age. Viagra works by allowing breaking down of nitric acids into smaller compounds to allow the enzymes to work on the blood tissues. Thereby Viagra can be ineffective in cases where there is no baseline nitric acid.
  • Viagra is prescribed in cases of psychogenic dysfunctions because it is also known to induce a sense of perceived sexual confidence in men.
  • Apart from the above mentioned causes some irrecoverable physical damage to the sex system due to accident, surgery etc cannot be overruled by usage of Viagra. Thus therapeutic it is but miraculous certainly not.

 


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