What Happens to Sildenafil, Tadalafil and Vardenafil Inside the Body

[ws_table id=”1″] A lot of attention has been given to what PDE5 inhibitors do to the human body, but now lets have a brief look at  how the the drugs – Viagra, Cialis and Levitra themselves change once they are introduced in the body. This article is not meant as an in depth reference, but aims to give a very basic outlook of the parameters involved.


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Pharmacokinetics is the study of how the body changes the drug and what happens to it inside the human body. If you notice – the half life of Cialis is much higher than Viagra or Levitra- this translates to higher active window, remember it works for upto 36 hours. Again the increased half life means slower onset of action meaning it takes longer than Viagra and Levitra to work but stays in the body for longer.


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The above statistic is interesting. What it tells us is that the effect of Cialis is unaffected with fatty food whereas Viagra and Levitra show decreased action time and concentration levels when a man eats fatty food.


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