Efficacy of Levitra & Cialis after Radical Retropubic Prostatectomy

Radical retropubic prostatectomy usually leaves the patient with considerable loss of erectile function. This article studies the efficacy of Levitra and Cialis in such cases.

Efficacy of Levitra (Vardenafil)

A prospective, double-blind, randomized, fixed dose ( 10 or 20 mg), placebo-controlled parallel-group study was done in order to study the efficacy as well as safety of vardenafil in men with symptoms of erectile dysfunction after bilateral or unilateral nerve sparing radical retropubic prostatectomy. Total number of people who participated was 440, but 25% of this number left the study before completion and their main reason to leave was response not being sufficient. IIEF, the SEP2 and SEP3 questions and the GAQ were used to assess the efficacy. About 80% of the subjects reported earlier use of sildenafil and out of those, 96% had observed improvement to a great degree.

When the study ended, both the doses of vardenafil proved to be far better than placebo for all efficacy measures (p<.001) There were reports of improved erections up to 66% and 60% in men who had taken vardenafil 20 mg and 10 mg respectively. Severity of ED at the beginning, even when severity at all levels improved when doses of vardenafil were given, is something that decides the response to vardenafil. Rhinitis, headache, sinusitis, flushing, nausea and dyspepsia were some of the adverse effects that were reported every now and then with both the doses of vardenafil.

Efficacy of Cialis (Tadalafil)

In men who had had a bilateral nerve sparing radical retropubic prostatectomy, study of the efficiency and safety of tadalafil 20 mg was done in a randomized, placebo-controlled, parallel-group, double-blind multi center through a 12 week trial. IIEF, SEP 2( (“Were you successful in inserting your penis into your partner’s vagina?”) and SEP 3 (“Did your erection persistent enough for you to have successful intercourse?”), EDITS and the GAQ were a part of the efficacy measures. Randomization of 303 men was done in all(2:1 ratio), tadalafil was assigned to 161 and placebo was assigned to 76 fur the purpose of study completion. Out of the tadalafil group, 8% men left in between because of the unavailable therapeutic response and similarly 9.8% left from the placebo group.  Improvement was much better in terms of measures of efficacy(p<.001) for the men who received tadalafil. As compared to 23% of men randomized to placebo(p<.001) and 24% of men with proof of post operative tumescence randomized to placebo, the erection was 63% and 72% respectively for the men taking tadalafil.

26.5% men in placebo group and 53`% men in the tadalafil group (p<.001) experienced one or more than one negative effects. Dyspepsia was more frequent in subjects with tadalafil as compared to those in placebo group (12% vs. 1%, p<.001), and similarly were myalgia (6% vs. 0, p=.006) and headache (20% vs. 6%, p<.001). The side effects are temporary and is expected and accepted as part of treatment with PDE5 inhibitors.

Conclusion

Levitra and Cialis eased erectile dysfunction post retropubic prostatectomy and helped many men perform successful intercourse and achieve sexual satisfaction.


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