Cialis Clinical Trials

In order to analyze the treatment contentment as well as the efficacy of on-demand Cialis in men who have slight to high intensity erectile dysfunction (ED), this randomized, parallel group, double-blind, placebo-controlled study was required.

After having been a part of 4 week treatment free run in period, three classes based on grimness were created for the patients by the International Index of Erectile Function (IIEF) Erectile Function (EF) domain score were arbitrated by analyzing patient response to Cialis and placebo over a time period of 12 weeks. There was difference in the efficacy endpoints from the initials in IIEF EF domain scores, reactions to the Global Assessment Questions (GAQ) as well as in the reactions to Sexual Encounter Profile diary (SEP).

A total of 443 men participated in the trial and out of them, the number of men who were part of the final intent-to-treat group was 409 (average age, 52 years). A balance was created between the treatment groups for average baseline demographics as per ED severity measures. In every IIEF EF severity group (mild, moderate and severe), the percentage of patients for placebo was 47, 30 and 23 and for tadalafil patients, it was 48, 29 and 23 respectively. Cialis(Tadalafil) was found to be better than placebo in all major issues of efficacy (IIEF EF domain scores, SEP15, GAQ1; p<0.001) and a significant 64% of the patients on Cialis were able to get a normal IIEF EF domain score in the end whereas only 16% of the placebo patients(p<.001) were able to get this.

The EDITS questionnaire was completed by a total of 185 patients (Cialis was given to 137 and placebo was given to 48), the median EDITS score of patients treated with tadalafil was 84 (95% CI 80, 86) and this was much more than 41 (the median EDITS score of patients that were given placebo (95%CI 32, 59; p<0.001; Wilcoxon test)). 87% of the tadalafil treated patients were found to be satisfied with their treatment and their final EDITS scores were greater than 50. However placebo patients (p<.001) faced less negative effects in comparison to tadalafil patients as was expected. Flushing (0% vs. 4.6%) and headache ( 1.9% vs. 7.2%) were among the major negative effects. Back pain in one patient made him stop the Cialis treatment.

cialis treatment satisfaction chart

Cialis 20 mg, when given to men with mild to severe ED, notably improves erectile function, has better tolerance and shows better treatment satisfaction in comparison to placebo. This study is first in the field of giving data about efficacy of tadalafil in East European men with erectile dysfunction and it is also the first study which has the ability to measure satisfaction in men treated with Cialis.


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