Efficacy of Cialis On Radiation Therapy Induced ED

radiation therapy prostate cancerRadiotherapy is commonly prescribed treatment to prostate cancer patients. Recent studies have observed a 38% post radiotherapy erectile dysfunction (ED) rate after a span of 3 years. Lets look at some clinical trial results that discussed the efficacy of Cialis in such patients Clinical Trial included study on 51 patients with a mean age of 65 years (range 50 to 80).  39% of men had comorbidity ( diabetes and/or hypertension). There was a mean difference of 39 months (range 15 to 55) between 3D-CRT completion and inclusion in the study and the mean dose given by linear accelerator was 70Gy (range 66 to 78), with 23 MV (range 18 to 25) mean energy. Application of three field 3D-CRT technique was done and prostate gland (with or without seminal vesicles) was the clinical target volume.

After the double-blind phase of the study, a 6 week open-label phase of trial was performed where the patients were given 20 mg tadalafil. After the run-in period, the two treatments in the double-blind phase and the open-label extension, the IIEF domain scores of the patients are calculated.

The crucial measures of efficacy of the IIEF was the EF domain and it is the sum of response related points to a global questionnaire. Wilcoxon ‘s matched pair test and the Mann-Whitney U test were used for within-group and between-group comparison of data respectively.

51 out of 60 patients completed the open-label phase and their scored with tadalafil were higher in the double-blind phase for the EF domain (P=0.03). There were no acute side effects. 84% improvement was observed in erections as compared to 72% in double-blind phase and success of intercourse improved by 69%, which was 55% for double-blind phase. It was reported by 17 patients that there had been improvement in their spontaneous erection with Cialis.

There were no side effects serious enough to stop the drug usage. The episodes of headache and dyspepsia were less with open-label study in comparison with double-blind phase.

Approximately 40% of the patients treated with PCa, go on to report ED in the next 1-3 years. One of the effective medicine to help in such cases are Cialis and Viagra. Cialis remains in effect till 36 hours after intake and its effect is in no way changed with the consumption of food or alcohol. Both these drugs help in reestablishing erectile response to sexual stimulation in ED affected patients.

The conclusion is that Cialis is an effective oral medicine to cure ED affected men (after RT for Pca ). Its 20 mg dose is effective, tolerant and with no major side effects.


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